BICYCLE THERAPEUTICS PLC BCYC

Healthcare SIC 2834 - Pharmaceutical Preparations NAICS Manufacturing › Chemical Manufacturing › Pharmaceutical and Medicine Manufacturing › Pharmaceutical Preparation Manufacturing derived Nasdaq

We are a clinical-stage pharmaceutical company developing a novel class of medicines, which we refer to as Bicycle® molecules, for diseases that are underserved by existing therapeutics. Bicycle molecules are fully synthetic short peptides constrained to form two loops which stabilize their structural geometry. This constraint facilitates target binding with high affinity and selectivity, making Bicycle molecules attractive candidates for drug development. Bicycle molecules are a unique therapeutic modality combining the pharmacology usually associated with a biologic with the manufacturing and pharmacokinetic, or PK, properties of a small molecule. The relatively large surface area presented by Bicycle molecules allows targets to be drugged that have historically been intractable to non-biological approaches. Bicycle molecules are excreted by the kidney rather than the liver and have shown no significant signs of immunogenicity to date, qualities which we believe explain the molecules' favorable toxicological profile.

Last close 3.55 2026-10-23
Market cap $247.8M estimated share count
52-week range 3.33 - 9.08

BCYC is a depositary receipt: one BCYC stands for 1 share of this company, per the cover page of its latest 10-K. The market cap and the multiples above are stated per receipt; the statements below, including EPS, are as filed and are per underlying share.

Valuation FY2025 figures against the last close

P/S3.4x
P/E—
P/FCF—
EV/EBITDA—
Dividend yield—
Diluted EPS-3.16

Annual financial statements

Income statement

Fiscal year FY2025FY2024FY2023FY2022FY2021FY2020FY2019FY2018FY2017FY2016
Revenue $72.6M$35.3M$27.0M$14.5M$11.7M$10.4M$13.8M$7.1M$2.1M—
R&D $240.3M$173.0M$156.5M$81.6M$44.9M$33.1M$25.5M$20.8M$11.9M—
SG&A $79.4M$72.2M$60.4M$49.5M$32.4M$29.2M$14.6M$8.1M$6.4M—
Total operating expenses $319.7M$245.1M$216.9M$131.1M$77.3M$62.4M$40.1M$28.9M$18.3M—
Operating income -$247.1M-$209.9M-$189.9M-$116.7M-$65.6M-$52.0M-$26.3M-$21.7M-$16.2M—
Interest expense $206.0K$1.7M$3.3M$3.3M$3.0M$457.0K————
Pre-tax income -$218.8M-$173.8M-$179.2M-$114.2M-$68.5M-$51.7M-$30.9M-$22.2M-$16.3M—
Income tax $152.0K$4.8M$1.5M$1.5M$1.7M$724.0K$254.0K$396.0K$23.0K—
Net income -$219.0M-$169.0M-$180.7M-$112.7M-$66.8M-$51.0M-$30.6M-$21.8M-$16.3M—
EPS, basic -3.16-2.90-5.08-3.80-2.67-2.66-2.77———
EPS, diluted -3.16-2.90-5.08-3.80-2.67-2.66-2.77-49.78-48.81—
Shares, diluted (wtd. avg.) 69.3M58.2M35.6M29.7M25.1M19.1M11.0M———

Balance sheet

Fiscal year FY2025FY2024FY2023FY2022FY2021FY2020FY2019FY2018FY2017FY2016
Cash and equivalents $628.1M$879.5M$526.4M$339.2M$438.7M$136.0M$92.1M$63.4M$67.7M$9.4M
Receivables $0$0$0$2.0M$1.0M$5.5M$201.0K$5.0M——
Total current assets $682.9M$928.6M$561.9M$369.4M$458.6M$155.7M$104.1M$76.8M——
Property, plant and equipment $6.0M$9.5M$14.5M$19.1M$3.1M$2.3M$2.3M$1.8M——
Total assets $717.6M$956.9M$595.3M$410.6M$479.8M$161.2M$110.2M$81.6M——
Accounts payable $9.7M$15.8M$13.1M$6.5M$2.7M$1.4M$1.9M$1.9M——
Total current liabilities $57.0M$67.2M$69.5M$53.3M$36.2M$23.1M$8.8M$8.9M——
Long-term debt ——$30.7M$30.3M$29.9M$14.5M————
Total liabilities $107.6M$163.8M$224.4M$139.8M$133.5M$65.7M$17.0M$29.3M——
Retained earnings -$899.8M-$680.8M-$511.8M-$331.1M-$218.4M-$151.6M-$100.5M-$69.9M——
Total equity $610.0M$793.1M$370.9M$270.8M$346.3M$95.5M$93.2M-$69.8M-$47.2M-$33.8M

Cash flow

Fiscal year FY2025FY2024FY2023FY2022FY2021FY2020FY2019FY2018FY2017FY2016
Operating cash flow -$249.7M-$164.7M-$60.6M-$86.1M-$14.8M-$17.8M-$28.6M-$26.1M-$1.4M—
Depreciation and amortisation $6.4M$7.2M$6.5M$3.7M$1.4M$1.3M$960.0K$712.0K$332.0K—
Stock-based compensation $39.5M$38.1M$32.5M$26.8M$12.1M$6.5M$3.1M$1.0M$515.0K—
Capital expenditure $2.4M$1.2M$2.9M$19.0M$2.0M$1.2M$1.6M$1.2M$1.1M—
Investing cash flow -$2.4M-$1.2M-$2.9M-$19.0M-$2.0M-$1.2M-$1.6M-$1.2M-$1.1M—
Financing cash flow -$131.0K$519.8M$250.0M$6.7M$320.7M$62.8M$58.4M$25.4M$57.9M—

Figures as tagged in each year's own filing, in US dollars. A year restated by a later filing shows the restated figure. Capital expenditure, dividends and buybacks are cash out, shown positive. A line the filer does not report is not listed. Latest from accession 0001104659-26-046806.

Plot the figures US dollars

Income statement Revenue Cost of revenue Gross profit R&D SG&A Total operating expenses Operating income Interest expense Pre-tax income Income tax Net income EPS, basic EPS, diluted Shares, diluted (wtd. avg.)
Balance sheet Cash and equivalents Short-term investments Receivables Inventory Total current assets Property, plant and equipment Goodwill Other intangibles Total assets Accounts payable Short-term debt Total current liabilities Long-term debt Total liabilities Retained earnings Total equity
Cash flow Operating cash flow Depreciation and amortisation Stock-based compensation Capital expenditure Investing cash flow Financing cash flow Dividends paid Buybacks
  • Revenue
  • Gross profit
  • Net income
Revenue, Gross profit, Net income by fiscal year, in US dollars The same figures are in the table below this chart. -300M -200M -100M 0 100M Revenue, FY2017: 2.1M Net income, FY2017: -16.3M Revenue, FY2018: 7.1M Net income, FY2018: -21.8M Revenue, FY2019: 13.8M Net income, FY2019: -30.6M Revenue, FY2020: 10.4M Net income, FY2020: -51M Revenue, FY2021: 11.7M Net income, FY2021: -66.8M Revenue, FY2022: 14.5M Net income, FY2022: -112.7M Revenue, FY2023: 27M Net income, FY2023: -180.7M Revenue, FY2024: 35.3M Net income, FY2024: -169M Revenue, FY2025: 72.6M Net income, FY2025: -219M FY2016 FY2017 FY2018 FY2019 FY2020 FY2021 FY2022 FY2023 FY2024 FY2025
Fiscal year FY2016FY2017FY2018FY2019FY2020FY2021FY2022FY2023FY2024FY2025
Revenue — $2.1M $7.1M $13.8M $10.4M $11.7M $14.5M $27.0M $35.3M $72.6M
Gross profit — — — — — — — — — —
Net income — -$16.3M -$21.8M -$30.6M -$51.0M -$66.8M -$112.7M -$180.7M -$169.0M -$219.0M

Recent filings and events

  • Officer or director change Someone at the top arrived or left. The item covers everything from a board retirement to a chief executive being removed, and only the filing itself says which. Item 5.02
  • Results announced The quarterly or annual earnings release. Arrives four times a year from almost every company here. Item 2.02
  • Shareholder vote The results of the annual meeting or a special vote. Item 5.07
  • Other event The catch-all. The company chose to disclose something that fits no other item, so the content is whatever it says it is. Item 8.01
  • Results announced Item 2.02
  • Other event Item 8.01
  • Annual report filed A new 10-K. The figures and the business description on this site come from it. Form 10-K
  • Results announced Item 2.02
  • Officer or director change Item 5.02
  • Officer or director change Item 5.02
  • Other event Item 8.01
  • Results announced Item 2.02

Item numbers are Form 8-K's own, and a filing date is up to four business days after the thing it reports. The same feed across the whole market.

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