ALNYLAM PHARMACEUTICALS, INC. ALNY

Healthcare SIC 2834 - Pharmaceutical Preparations NAICS Manufacturing › Chemical Manufacturing › Pharmaceutical and Medicine Manufacturing › Pharmaceutical Preparation Manufacturing derived Nasdaq

Alnylam Pharmaceuticals, Inc. (also referred to as Alnylam, the Company, we, our or us) is a global commercial-stage biopharmaceutical company developing novel therapeutics based on ribonucleic acid interference, or RNAi. RNAi is a naturally occurring biological pathway within cells for sequence-specific silencing and regulation of gene expression. By harnessing the RNAi pathway, we have pioneered a new class of innovative medicines, known as RNAi therapeutics. RNAi therapeutics are comprised of small interfering RNA, or siRNA, that function upstream of conventional medicines by potently silencing messenger RNA, or mRNA, that encode for proteins implicated in the cause or pathway of disease, thus preventing them from being made. We believe this is a revolutionary approach with the potential to transform the care of patients across a broad range of disease areas and indications. To date, our efforts to advance this revolutionary approach have yielded the approval of six first-in-class RNAi-based medicines: AMVUTTRA® (vutrisiran), ONPATTRO® (patisiran), GIVLAARI® (givosiran), OXLUMO® (lumasiran), Leqvio® (inclisiran) and Qfitlia® (fitusiran).

Last close 224.03 2026-10-23
Market cap $29.98B 2026-06-30 share count
52-week range 197.81 - 484.61

Valuation FY2025 figures against the last close

P/S8.1x
P/E96.2x
P/FCF64.4x
EV/EBITDA53.8x
Dividend yield—
Diluted EPS2.33

Annual financial statements

Income statement

Fiscal year FY2025FY2024FY2023FY2022FY2021FY2020FY2019FY2018FY2017FY2016
Revenue $3.71B$2.25B$1.83B$1.04B$844.3M$492.9M$219.8M$74.9M$2.9M$47.2M
Cost of revenue $677.2M$306.5M$268.2M$140.2M$115.0M$74.2M$25.1M$1.8M$0—
Gross profit $3.04B$1.94B$1.56B$897.2M$729.3M$418.7M$194.7M$73.1M$2.9M—
R&D $1.32B$1.13B$1.00B$883.0M$792.2M$654.8M$655.1M$505.4M$390.6M$382.4M
SG&A $1.21B$975.5M$795.6M$770.7M$620.6M$588.4M$479.0M$382.4M$199.4M$89.4M
Total operating expenses $3.21B$2.43B$2.11B$1.82B$1.55B$1.32B$1.16B$889.6M$590.0M$471.7M
Operating income $501.6M-$176.9M-$282.2M-$785.1M-$708.7M-$828.4M-$939.4M-$814.7M-$500.1M-$424.6M
Interest expense $252.6M$141.9M$121.2M$156.0M$143.0M$84.5M$0$0——
Pre-tax income $323.2M-$377.4M-$433.5M-$1.13B-$852.1M-$855.6M-$885.3M-$760.7M-$490.9M-$410.1M
Income tax $9.4M$99.2M$6.7M$4.2M$680.0K$2.7M$863.0K$823.0K$0$0
Net income $313.7M-$278.2M-$440.2M-$1.13B-$852.8M-$858.3M-$886.1M-$761.5M-$490.9M-$410.1M
EPS, basic 2.39-2.18-3.52-9.30-7.20-7.46-8.11———
EPS, diluted 2.33-2.18-3.52-9.30-7.20-7.46-8.11-7.57-5.42-4.79
Shares, diluted (wtd. avg.) 134.7M127.7M124.9M121.7M118.5M115.0M109.3M———

Balance sheet

Fiscal year FY2025FY2024FY2023FY2022FY2021FY2020FY2019FY2018FY2017FY2016
Cash and equivalents $1.66B$966.4M$812.7M$868.6M$822.2M$499.0M$547.2M$420.1M$645.4M$193.6M
Short-term investments $1.25B$1.72B$1.62B$1.30B$1.55B$1.33B$975.0M$662.8M$1.05B$424.2M
Receivables $777.6M$405.3M$327.8M$238.0M$198.6M$102.4M$43.0M$18.8M$34.0M$23.3M
Inventory $82.7M$78.5M$89.1M$129.0M$86.4M$75.2M$56.3M$24.1M——
Total current assets $4.05B$3.30B$2.98B$2.69B$2.81B$2.61B$1.72B$1.20B$1.76B$671.9M
Property, plant and equipment $513.1M$502.8M$526.1M$523.5M$502.0M$465.0M$425.2M$320.7M$181.9M$114.6M
Total assets $4.97B$4.24B$3.83B$3.55B$3.64B$3.41B$2.40B$1.57B$1.99B$1.26B
Accounts payable $115.7M$88.4M$55.5M$98.1M$73.4M$52.0M$49.9M$59.7M$28.4M$54.5M
Total current liabilities $1.47B$1.19B$967.8M$767.9M$695.7M$585.3M$352.6M$179.5M$144.3M$131.7M
Total liabilities $4.18B$4.17B$4.05B$3.70B$3.06B$2.39B$956.4M$272.8M$228.3M$342.6M
Retained earnings -$6.70B-$7.29B-$7.01B-$6.57B-$5.44B-$4.59B-$3.73B-$2.84B-$2.15B-$1.66B
Total equity $789.2M$67.1M-$220.6M-$158.2M$588.2M$1.02B$1.44B$1.30B$1.77B$920.2M

Cash flow

Fiscal year FY2025FY2024FY2023FY2022FY2021FY2020FY2019FY2018FY2017FY2016
Operating cash flow $524.1M-$8.3M$104.2M-$541.3M-$641.7M-$615.0M-$278.4M-$562.6M-$382.8M-$307.7M
Depreciation and amortisation $55.7M$56.7M$54.1M$44.5M$47.6M$34.8M$17.2M$15.2M$11.9M$15.1M
Stock-based compensation $348.2M$272.1M$221.7M$230.6M$165.7M$139.9M$174.8M$157.8M$92.8M$75.5M
Capital expenditure $58.7M$34.3M$62.2M$72.1M$76.4M$70.4M$140.2M$126.9M$104.2M$64.6M
Investing cash flow $436.3M-$116.8M-$336.4M$169.4M-$273.3M-$435.5M-$417.7M$272.9M-$290.4M$142.6M
Financing cash flow -$305.2M$294.2M$172.1M$425.8M$1.25B$995.0M$823.2M$65.5M$1.12B$177.8M

Figures as tagged in each year's own filing, in US dollars. A year restated by a later filing shows the restated figure. Capital expenditure, dividends and buybacks are cash out, shown positive. A line the filer does not report is not listed. Latest from accession 0001628280-26-023923.

Plot the figures US dollars

Income statement Revenue Cost of revenue Gross profit R&D SG&A Total operating expenses Operating income Interest expense Pre-tax income Income tax Net income EPS, basic EPS, diluted Shares, diluted (wtd. avg.)
Balance sheet Cash and equivalents Short-term investments Receivables Inventory Total current assets Property, plant and equipment Goodwill Other intangibles Total assets Accounts payable Short-term debt Total current liabilities Long-term debt Total liabilities Retained earnings Total equity
Cash flow Operating cash flow Depreciation and amortisation Stock-based compensation Capital expenditure Investing cash flow Financing cash flow Dividends paid Buybacks
  • Revenue
  • Gross profit
  • Net income
Revenue, Gross profit, Net income by fiscal year, in US dollars The same figures are in the table below this chart. -2B 0 2B 4B Revenue, FY2016: 47.2M Net income, FY2016: -410.1M Revenue, FY2017: 2.9M Gross profit, FY2017: 2.9M Net income, FY2017: -490.9M Revenue, FY2018: 74.9M Gross profit, FY2018: 73.1M Net income, FY2018: -761.5M Revenue, FY2019: 219.8M Gross profit, FY2019: 194.7M Net income, FY2019: -886.1M Revenue, FY2020: 492.9M Gross profit, FY2020: 418.7M Net income, FY2020: -858.3M Revenue, FY2021: 844.3M Gross profit, FY2021: 729.3M Net income, FY2021: -852.8M Revenue, FY2022: 1B Gross profit, FY2022: 897.2M Net income, FY2022: -1.1B Revenue, FY2023: 1.8B Gross profit, FY2023: 1.6B Net income, FY2023: -440.2M Revenue, FY2024: 2.2B Gross profit, FY2024: 1.9B Net income, FY2024: -278.2M Revenue, FY2025: 3.7B Gross profit, FY2025: 3B Net income, FY2025: 313.7M FY2016 FY2017 FY2018 FY2019 FY2020 FY2021 FY2022 FY2023 FY2024 FY2025
Fiscal year FY2016FY2017FY2018FY2019FY2020FY2021FY2022FY2023FY2024FY2025
Revenue $47.2M $2.9M $74.9M $219.8M $492.9M $844.3M $1.04B $1.83B $2.25B $3.71B
Gross profit — $2.9M $73.1M $194.7M $418.7M $729.3M $897.2M $1.56B $1.94B $3.04B
Net income -$410.1M -$490.9M -$761.5M -$886.1M -$858.3M -$852.8M -$1.13B -$440.2M -$278.2M $313.7M

Recent filings and events

  • Results announced The quarterly or annual earnings release. Arrives four times a year from almost every company here. Item 2.02
  • Officer or director change Someone at the top arrived or left. The item covers everything from a board retirement to a chief executive being removed, and only the filing itself says which. Item 5.02
  • Shareholder vote The results of the annual meeting or a special vote. Item 5.07
  • Results announced Item 2.02
  • Officer or director change Item 5.02
  • Annual report filed A new 10-K. The figures and the business description on this site come from it. Form 10-K
  • Results announced Item 2.02
  • Results announced Item 2.02
  • Other event The catch-all. The company chose to disclose something that fits no other item, so the content is whatever it says it is. Item 8.01
  • Officer or director change Item 5.02
  • Results announced Item 2.02
  • Material agreement signed The company entered an agreement outside the ordinary course of business - a large contract, a credit facility, a merger agreement. Item 1.01

Item numbers are Form 8-K's own, and a filing date is up to four business days after the thing it reports. The same feed across the whole market.

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